When developing with Mono for an app to be run on Windows and Mac OSX (and maybe Linux) which would you suggest, WinForms or GtkSharp for the GUI and why?>
What platform will most of the users of your app have? If most of the users will be Windows users, use Winforms, but if most of the users will be Linux users, use Gtk#. I wouldn't know which one works best on OSX.
Read this article also: http://www.mono-project.com/Gui_Toolkits