Following up my previous question: if and how would it be possible to take RGB based TIFF files and convert them over to CMYK with standard .NET (3.5) functionality?
No, I don't think that's possible using standard GDI+ wrappers (System.Drawing).
GDI+ only supports RGB. CMYK based images can be read by GDI+ (implicit conversion to RGB), but CMYK based images can't be written.
You might want to try something like GraphicsMill, which supports CMYK.