I am struggling with breakPoint issue in VS 2012 for more than hours. I am from eclipse background, there I never heard about such issues.
Problem :<
After opening and closing VS, rebooting the PC with all with no chance, this workaround worked for me in VS 2012 ( Ver 11.0.50727.1 RTMREL ):
In Project Property Pages, under Start Options, in Debugger section, only ASP.NET was enabled. As soon as I enabled Native Code and SQL Server, that red circle with plus sign inside, enabled again. No idea why this worked! No active connection in Server Explorer nor using any native code in the project!