When I am trying to run an ASP.Net Core project in Visual Studio 2015, a Microsoft Visual Studio dialog appears \"The project doesn\'t know how to run the profile IIS Expres
I had this same issue and after digging around for a while I discovered that I had dotnet preview v1.0.0-preview2 installed under Programs Files (x86) and a non-preview version in x64. I think VS is launching the x86 (preview) version but expecting to see the full version. To fix this, I did the following.
When I did all of the above, I was able to start up the site in IIS Express from VS.