I am trying to install python bindings for the enchant library (pyenchant), according to the readme, it should be as simple as running python setup.py install
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You need to install the enchant library first. On the download page pyenchant indicates that it is a prerequisite if you are building from source. (There are pre-build binaries listed for python 2.5 and 2.6 as well.)
I just installed enchant via homebrew on OS X 10.7 and then pyenchant installed without a problem.
If you decide to use homebrew for installing enchant, note that I had to brew install pkg-config
separate as the recipe doesn't seem to install it as a dependancy (and fails as a result).