Protection against automation

Question

One of our next projects is supposed to be a MS Windows based game (written in C#, with a winform GUI and an integrated DirectX display-control) for a customer who wants to

Answer 1

You should look into what goes into Punkbuster, Valve Anti-Cheat, and some other anti-cheat stuff for some pointers.

Edit: What I mean is, look into how they do it; how they detect that stuff.