Background:
I am aware of this SO question about Transactional NTFS (TxF) and this article describing how to use it, but I am looking for <
Unfortunately, it appears that the answer is "No."
In nearly two weeks (one week with a 100 point bounty) and 156 views, no one has answered that they have used TxF for any high-volume applications as I described. I can't say this was unexpected, and of course I cannot prove a negative, but it appears this feature of Windows is not well known or frequently used, at least by active members of the SO community at the time of writing.
If I ever get around to writing some kind of proof of concept, I'll post here what I learn.