Avoid using IN(...) when selecting on indexed fields, It will kill the performance of SELECT query.
I found this here: https://wikis.ora
Prior to MySQL 5.0 it seems that mySQL would only use a single index for a table. So, if you had a SELECT * FROM tbl WHERE (a = 6 OR b = 33)
it could chooose to use either the a index or the b index, but not both. Note that it says fields, plural. I suspect the advice comes from that time and the work-around was to union the OR results, like so:
SELECT * FROM tbl WHERE (a = 6)
UNION
SELECT * FROM tbl WHERE (b = 33)