You can also hack the insert operation :
INSERT INTO mytable (id, a, b, c)
VALUES (1, 'a1', 'b1', 'c1'),
(2, 'a2', 'b2', 'c2'),
(3, 'a3', 'b3', 'c3'),
(4, 'a4', 'b4', 'c4'),
(5, 'a5', 'b5', 'c5'),
(6, 'a6', 'b6', 'c6')
ON DUPLICATE KEY UPDATE id=VALUES(id),
a=VALUES(a),
b=VALUES(b),
c=VALUES(c)