I have a multi-project solution that I was building in Visual Studio 2013 and it was working fine but now that I have upgraded to Visual Studio 2015 I can no longer hit brea
I had a similar problem, when I created a new build configuration. After hunting around settings in VS2015, I noticed that there were no *.pdb files in my build output. Obviously, debugging would not work if there were *.pdb files.
The fix for me was to go into every project's properties -> 'build' page -> click the "advanced" button at the bottom of the page -> In the dialog's 'Output' section, I set "debug info" to equal "full".
Basically, I created a new solution and project and copied all the build properties into the solution that the debugger was not stopping at break points anymore. In addition to the setting above, I also changed the following setting to match the default debug settings: