I personally hate regions. The only code that should be in regions in my opinion is generated code.
When I open file I always start with Ctrl+M+O. This folds to method level. When you have regions you see nothing but region names.
Before checking in I group methods/fields logically so that it looks ok after Ctrl+M+O.
If you need regions you have to much lines in your class. I also find that this is very common.
region ThisLooksLikeWellOrganizedCodeBecauseIUseRegions
// total garbage, no structure here
endregion
