In VS2012, my web project debugs fine like always. I use IIS Express. Today, I installed VS 2013 and when I press F5 to debug, I get
The answer was given by @ScottG in his edit, but here's a clearer explanation:
Open your Web Project Properties settings, click the Web tab, and under 'Debuggers,' unclick 'Silverlight.' Obviously, if you're needing to debug silverlight another solution will have to be found, until the VStudio team fixes this bug.