I love programming with .NET, especially C# 3.0, .NET 3.5 and WPF. But what I especially like is that with Mono .NET is really platform-independent.
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Update: Since people keep upvoting this, I want to point out it is long since out of date. Mono got acquired by MS years ago, and their posture regarding open-source has changed, so consider this post obsolete. (As obsolete as the WPF framework itself, heh).
Mono is in a bit of an uncomfortable position when it comes to Microsoft APIs such as Winforms and WPF. A subset of the .Net technology is an ECMA standard, but free implementations of these APIs are probably on shakier legal ground. I believe this was a large factor in the covenant between Novell and Microsoft, which is good for Novell customers. But people who use Mono that aren't customers of Novell aren't protected. For this reason a lot of people in the F/OSS community look askance at Mono despite its technical merits.
For this reason, Gtk# will always be preferred, since it is truly Free. Many people consider it to be superior to Winforms anyway. As far as WPF is concerned, it will almost certainly be a low priority for Novell. They may implement it eventually, but I would expect Moonlight to be the closest you could get for the forseeable future.
Since posting this, Microsoft has extended their covenant to anybody who implements the ECMA 334 & 335 standards.