On running my window application. if the user press ctrl+alt+del i need to disable these buttons..is there any method
I certainly hope not - the Ctrl-Alt-Del key combination is intercepted by the operating system and is never passed to applications. This is a security measure: if the user presses Ctrl-Alt-Del, it is guaranteed that what the user will see is the login screen / task manager (depending on which Windows version you have), not some application that tries to steal his password (I'm not implying that that's your intention, but such applications are what Ctrl-Alt-Del is designed to prevent).