psyco seems to be quite helpful in optimizing Python code, and it does it in a very non-intrusive way.
Therefore, one has to wonder. Assuming you\'re always on a x8
It also depends where your bottleneck is. I am mostly doing web apps and there the bottlenecks are probably more IO and database. So you should know where to optimize.
Also beware that maybe you first should think about your code instead of directly throwing psyco at it. So I agree with Devin, that algorithm optimizations should come first and they might have a smaller chance of unwanted sideeffects.