The title really says it all. A friend of mine told me he knows someone who can program in binary. I\'ve never heard of someone programming in binary and a few quick Google
There are some esoteric programming languages. They are used as experiments, and are rather impractical, but one, called BrainF**k (yes, it is actually a real thing) uses eight different characters to modify byte values. Those kind of languages are about as close as you can get.