Yes, fluid websites are worth creating
As you said, it looks good and reasonable when you plan properly at design phase.
Your doubt about the impact of Ctrl + Scrollbar is not a big deal.
This feature is primarily for accessibility, to make text more readable by increasing the size.
However, if you mention all your sizes in Pixels (px) it won't happen.
Proper adjustment happens only when you use "em" to specify size. So you have a way to turn it on/off
