Best way to check if column returns a null value (from database to .net application)

Question

I have a table with a DateTime column the column can have NULL values

Now I connect to the database using an ODBC connection and get the value into a DataTable in .n

Answer 1

If we are using EF and reading the database element in while loop then,

   using( var idr = connection, SP.......)
   {
       while(idr.read())
       {
          if(String.IsNullOrEmpty(idr["ColumnNameFromDB"].ToString())
          //do something
       }
   }