In this particular case I need to run .complicated NET application for Linux. By complicated i mean - that project was developed for 3 years and i don\'t wa
You can install the full .Net Framework 4.x in wine using winetricks, then run your app.
Wine supports serial ports, so I don't see any inconvenience.
I made a video showing this:
https://www.youtube.com/watch?v=60yyWBLXv1k
In the video, you can see the windows taskbar. Don't worry about it. This is because it is running in WSL2. But these steps work perfectly in Linux.
Regards