NumPy is an extremely useful library, and from using it I\'ve found that it\'s capable of handling matrices which are quite large (10000 x 10000) easily, but begins to strug
Are you asking how to handle a 2,500,000,000 element matrix without terabytes of RAM?
The way to handle 2 billion items without 8 billion bytes of RAM is by not keeping the matrix in memory.
That means much more sophisticated algorithms to fetch it from the file system in pieces.