In my experience it seems that most people will tell you that it is unwise to force a garbage collection but in some cases where you are working with large objects that don\
Look at it this way - is it more efficient to throw out the kitchen garbage when the garbage can is at 10% or let it fill up before taking it out?
By not letting it fill up, you are wasting your time walking to and from the garbage bin outside. This analogous to what happens when the GC thread runs - all the managed threads are suspended while it is running. And If I am not mistaken, the GC thread can be shared among multiple AppDomains, so garbage collection affects all of them.
Of course, you might encounter a situation where you won't be adding anything to the garbage can anytime soon - say, if you're going to take a vacation. Then, it would be a good idea to throw out the trash before going out.
This MIGHT be one time that forcing a GC can help - if your program idles, the memory in use is not garbage-collected because there are no allocations.