If the number of UUID being generated follows Moore's law, the impression of never running out of GUID in the foreseeable future is false.
With 2 ^ 128 UUIDs, it will only take 18 months * Log2(2^128) ~= 192 years, before we run out of all UUIDs.
And I believe (with no statistical proof what-so-ever) in the past few years since mass adoption of UUID, the speed we are generating UUID is increasing way faster than Moore's law dictates. In other words, we probably have less than 192 years until we have to deal with UUID crisis, that's a lot sooner than end of universe.
But since we definitely won't be running them out by the end of 2012, we'll leave it to other species to worry about the problem.
