I have many users on my web site (20000-60000 per day), which is a download site for mobile files. I have remote access to my server (windows server 2008-R2).
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I encountered this error recently and after some brief investigation, found the cause to be that we were running out of space on the disk holding the database (less than 1GB).
As soon as I moved out the database files (.mdf and .ldf) to another disk on the same server (with lots more space), the same page (running the query) that had timed-out loaded within three seconds.
One other thing to investigate, while trying to resolve this error, is the size of the database log files. Your log files just might need to be shrunk.