There are loads of PHP exploits which can be disabled by settings in the PHP.ini file. Obvious example is register_globals, but depending on settings it may also be possible to include or open files from remote machines via HTTP, which can be exploited if a program uses variable filenames for any of its include() or file handling functions.
PHP also allows variable function calling by adding () to the end of a variable name -- eg $myvariable(); will call the function name specified by the variable. This is exploitable; eg if an attacker can get the variable to contain the word 'eval', and can control the parameter, then he can do anything he wants, even though the program doesn't actually contain the eval() function.
