Oracle\'s instructions specify setting DYLD_LIBRARY_PATH. This makes my application dependent on random users\' configuration and is very troublesome to set up.
How
If your goal is simply to run sqlplus on your MacBook, this might work for you. Remove the DYLD_LIBRARY_PATH environment variable from ~/.bashrc and replace it with an alias:
alias sqlplus="DYLD_LIBRARY_PATH=/Applications/instantclient_11_2 sqlplus"
Blog entry: sqlplus and DYLD_LIBRARY_PATH on Mac OS/X