Sometime I see many application such as msn, windows media player etc that are single instance applications (when user executes while application is running a new applicatio
I wrote a dedicated library for that https://sanyarnd.github.io/applocker
It is based on file-channel locking, so it will not block a port number, or deadlock application in case of power outage (channel is released once process is terminated).
Library is lightweight itself and has a fluent API.
It was inspired by http://www.sauronsoftware.it/projects/junique/, but it's based on file channels instead. And there are other extra new features.