Is a GUID unique 100% of the time?
Will it stay unique over multiple threads?
Yes, a GUID should always be unique. It is based on both hardware and time, plus a few extra bits to make sure it's unique. I'm sure it's theoretically possible to end up with two identical ones, but extremely unlikely in a real-world scenario.
Here's a great article by Raymond Chen on Guids:
https://blogs.msdn.com/oldnewthing/archive/2008/06/27/8659071.aspx