Consider the following code:
void Handler(object o, EventArgs e)
{
// I swear o is a string
string s = (string)o; // 1
//-OR-
string s = o as str
According to experiments run on this page: http://www.dotnetguru2.org/sebastienros/index.php/2006/02/24/cast_vs_as
(this page is having some "illegal referrer" errors show up sometimes, so just refresh if it does)
Conclusion is, the "as" operator is normally faster than a cast. Sometimes by many times faster, sometimes just barely faster.
I peronsonally thing "as" is also more readable.
So, since it is both faster and "safer" (wont throw exception), and possibly easier to read, I recommend using "as" all the time.