We are unable to connect to an HTTPS server using WebRequest
because of this error message:
The request was aborted: Could not create SSL/TLS secur
The top-voted answer will probably be enough for most people. However, in some circumstances, you could continue getting a "Could not create SSL/TLS secure channel" error even after forcing TLS 1.2. If so, you may want to consult this helpful article for additional troubleshooting steps. To summarize: independent of the TLS/SSL version issue, the client and server must agree on a "cipher suite." During the "handshake" phase of the SSL connection, the client will list its supported cipher-suites for the server to check against its own list. But on some Windows machines, certain common cipher-suites may have been disabled (seemingly due to well-intentioned attempts to limit attack surface), decreasing the possibility of the client & server agreeing on a cipher suite. If they cannot agree, then you may see "fatal alert code 40" in the event viewer and "Could not create SSL/TLS secure channel" in your .NET program.
The aforementioned article explains how to list all of a machine's potentially-supported cipher suites and enable additional cipher suites through the Windows Registry. To help check which cipher suites are enabled on the client, try visiting this diagnostic page in MSIE. (Using System.Net tracing may give more definitive results.) To check which cipher suites are supported by the server, try this online tool (assuming that the server is Internet-accessible). It should go without saying that Registry edits must be done with caution, especially where networking is involved. (Is your machine a remote-hosted VM? If you were to break networking, would the VM be accessible at all?)
In my company's case, we enabled several additional "ECDHE_ECDSA" suites via Registry edit, to fix an immediate problem and guard against future problems. But if you cannot (or will not) edit the Registry, then numerous workarounds (not necessarily pretty) come to mind. For example: your .NET program could delegate its SSL traffic to a separate Python program (which may itself work, for the same reason that Chrome requests may succeed where MSIE requests fail on an affected machine).