Obfuscation is one way, but it can\'t protect from breaking the piracy protection security of the application. How do I make sure that the application is not tampered with,
You can..
Microsoft SLP ServicesInishTech's Software Potential offers the ability to help protect code without affecting the functionality of your applications.
UPDATE: (Disclosure: I work on Eazfuscator.NET) What makes Microsoft SLP ServicesSoftware Potential different is the ability to virtualize the code, so you definitely can. Several years passed since the question was originally asked; today there are more products available that also work on a similar basis such as: