If its open it will be in the Workbooks collection:
Function BookOpen(strBookName As String) As Boolean
Dim oBk As Workbook
On Error Resume Next
Set oBk = Workbooks(strBookName)
On Error GoTo 0
If oBk Is Nothing Then
BookOpen = False
Else
BookOpen = True
End If
End Function
Sub testbook()
Dim strBookName As String
strBookName = "myWork.xls"
If BookOpen(strBookName) Then
MsgBox strBookName & " is open", vbOKOnly + vbInformation
Else
MsgBox strBookName & " is NOT open", vbOKOnly + vbExclamation
End If
End Sub