From CLR via C#:
When normalizing strings, it is highly
recommended that you use
ToUpperInvariant instead of
ToLowerInvariant because Microsoft has
optimized the code for performing
uppercase comparisons.
I remember one time my coworker always changed strings to uppercase before comparing. I've always wondered why he does that because I feel it's more "natural" to convert to lowercase first. After reading the book now I know why.