I like how the pycron package solves this problem.
import pycron
import time
while True:
if pycron.is_now('0 2 * * 0'): # True Every Sunday at 02:00
print('running backup')
time.sleep(60) # The process should take at least 60 sec
# to avoid running twice in one minute
else:
time.sleep(15) # Check again in 15 seconds