In a function that has no side-effects, there's no good reason to have more than a single return and you should write them in a functional style. In a method with side-effects, things are more sequential (time-indexed), so you write in an imperative style, using the return statement as a command to stop executing.
In other words, when possible, favor this style
return a > 0 ?
positively(a):
negatively(a);
over this
if (a > 0)
return positively(a);
else
return negatively(a);
If you find yourself writing several layers of nested conditions, there's probably a way you can refactor that, using predicate list for example. If you find that your ifs and elses are far apart syntactically, you might want to break that down into smaller functions. A conditional block that spans more than a screenful of text is hard to read.
There's no hard and fast rule that applies to every language. Something like having a single return statement won't make your code good. But good code will tend to allow you to write your functions that way.
