We\'re currently working on updating our asp.net web application (hosted on IIS 7.5) from .net framework v4.5 to v4.6.1. On small lower environments/local development in which S
The following article describes a new default connection string setting for SQL Server connections in .net 4.6.1.
https://blogs.msdn.microsoft.com/dataaccesstechnologies/2016/05/07/connection-timeout-issue-with-net-framework-4-6-1-transparentnetworkipresolution/
This was to solve one problem in some environments, but also caused the issue you are experiencing in other environments.
Basically, you'll want to add the following your connection string:
TransparentNetworkIPResolution=False;