import re
sentance = '''hello? there A-Z-R_T(,**), world, welcome to python. this **should? the next line#followed- by@ an#other %million^ %%like $this.'''
res = re.sub('[!,*)@#%(&$_?.^]', '', sentance)
print(res)
re.sub('["]') -> here you can add which symbol you want to remove