We have an application that is running on 5 (server) nodes (16 cores, 128 GB Memory each) that loads almost 70 GB data on each machine. This application is distributed and serve
The GC doesn't take into account the unmanaged heap. If you are creating lots of objects that are merely wrappers in C# to larger unmanaged memory then your memory is being devoured but the GC can't make rational decisions based on this as it only see the managed heap.
You end up in a situation where the GC collector doesn't think you are short of memory because most of the things on your gen 1 heap are 8 byte references where in actual fact they are like icebergs at sea. Most of the memory is below!
You can make use of these GC calls:
System::GC::AddMemoryPressure(sizeOfField);
System::GC::RemoveMemoryPressure(sizeOfField);
These methods allow the garbage collector to see the unmanaged memory (if you provide it the right figures)