So, I am using Matthew Ephraim\'s GhostscriptSharp, which is a simple C# wrapper for the unmanaged Win32 Ghostscript DLL in my ASP.Net MVC project. Some background:
Wha
Most likely the process running the web application does not have permission to write to the directories that you are using. I'd suggest creating some specific directory for the app to use and a local id to use to run the app pool, then give that id enough privileges to read/write the directory you've created.