I have recently upgraded from VS2012 RC to RTM, and since the upgrade to RTM, I can no longer access nuget. I receive the following error in the Manage NuGet Packages window.
The solution is in this answer:
Visual Studio 2010 nuget error: The underlying connection was closed: Could not establish trust relationship for the SSL/TLS secure channel
The problem is related to a bad SSL cert on the default Nuget package source.