Straightforward C#/Java code is
extremely difficult to parallelize
Not if you use the Task Parallel Library.
Whether F# becomes huge depends on whether the cost/benefit is there, which is not at all obvious. If .NET developers find out that they can write some programs in 1/3 of the time using a functional rather than an imperative approach (which I think might be true for certain types of programs), then there should be some motivation for F# adoption.
Paul Graham's story of his use of Lisp in a startup company is illustrative of this process. Lisp provided them with a huge competitive advantage, yet Lisp didn't take over the world, not because it wasn't powerful, but for other reasons, like lack of library support. That F# has access to the .NET framework gives it a fighting chance.
http://www.paulgraham.com/avg.html
