I run an application on the Azure application Standard: 1 Small plan. Framework is 4.6.1
This application is calling a SSL secured API. The SSL is published by StartCom
I ran across this error when hosting a client's certificate on Azure's App Services. The fix was to set WEBSITE_LOAD_CERTIFICATES in the App Settings.
You can set it as " * " to allow all certificates, or you can define specific certificate thumbprints to allow. See more info here.