The Psyco docs say:
Just for reference, Psyco does not work on any 64-bit systems at all. This fact is worth being noted again, now that the latest
Christian Tismer, one of the Psyco developers also seems to disagree with the "how hard could it be" - assumption (quoted from here):
Needs to come to x86-64? Why that! Seriously, I would love to do that, but this would be much harder than anybody would expect. Due to the way psyco is written, it would be really half a rewrite to releave it from its 32-bitterness. The 32 bit assumption is implicitly everywhere. It would be straight forward, if the memory model was all 64 bit. But no intel platform is that simple. so long, and thanks for all the fish -- chris
and
hum. It would cost at least 3 or 4 months of full-time work do do that, if not more. I doubt that I can get sponsorship for that.
If you want more details (firm inside knowledge of Psyco probably needed) I guess you can always try to ask on one of the psyco mailing lists ...