Both tools translate assembly instructions directly into machine code, but is it possible to determine which one produces the fastest and cleanest code?
I don't know about these two specific tools, but there are some instructions that can be encoded differently:
ADD AX,1
is either 05 01
or 81 c0 01
or fe c0
INT 3
is either cc
or cd 03
These are just a few examples off the top of my head of how assemblers can encode the same instruction differently, so the question does in fact make sense.