Best practices and tools for debugging differences between Debug and Release builds?

Question

I\'ve seen posts talk about what might cause differences between Debug and Release builds, but I don\'t think anybody has addressed from a development standpoint what is

Answer 1

One other "Best Practice", or rather a combination of two: Have Automated Unit Tests, and Divide and Conquer.

If you have a modular application, and each module has good unit tests, then you may be able to quickly isolate the errant piece.