It depends. (I love "it depends" questions)
It depends on the knowledge of the writer and reader. I used to think the use of Symbol#to_proc in Rails was unnecessarily arcane, for example, preferring
a.map { |e| e.downcase }
to
a.map(&:downcase)
Now I'm happy when I read it, although I still don't think to write it.
There are areas of libraries (Rails and others) where I have felt excessive and self-indulgent metaprogramming may have occurred but again the division between "too clever" and "really very clever indeed" is often paper-thin. DSLs are a good area: the ways in which "macros" are made available within classes (think of all that declarative goodness in things like ActiveRecord::Base or ActionController::Base) is very hard for a relative novice to understand and would probably seem like over-cleverness. It did to me. Now I find myself referencing the same code for guidance as I implement similar capabilities.