I was wondering how useful foreign keys really are in a database. Essentially, if the developers know what keys the different tables depend on, they can write the queries just
Not using referential integrity in a database is like not using seatbelts in cars. It will provide you with measurable improvements in taking you from A->B, but it will make "real" difference only in the most extreme cases. Why take the "risk" unless you really have to?
The underlaying reason people ask this question is always performance.
Foreign keys give the optimizer much more information to work with, and it will potentially produce better execution plans. It's not like a specific query will be % percent faster with enabled constraints, it's more like you effectively eliminate entire classes of problems due to bad execution plans. You also enable the optimizer to rewrite queries in ways that just isn't possible without the constraints (join elimination for example).
Starting right here, I would like to start a myth that referential integrity always increases performance in databases. I'm fairly confident that if 100 people designed their databases with full integrity checking, less than 5 people will actually have to consider spend a whopping 1 second to disable them for performance reasons. Out of those 5 people, there will be close to 0 people who find that they need to disable 100% of the constraints.
Spread the word ;)