when not to use CSS sprites?

Question

I want to know when not to use CSS sprites. CSS sprites works great, but are there any occasions when they create a lot of headaches?

Answer 1

We had a tough time when we wanted to position the image dynamically.

background-image: url(../images/a.gif);
background-repeat: no-repeat;
background-position: left bottom;

This is tricky (if not impossible) to do using a sprite.