We have an ASP.NET 4.0 application that draws from a database a complex data structure that takes over 12 hours to push into an in memory data structure (that is later stored in
In memory databases such as memcache or Redis are slow in comparison to HttpRuntime.Cache
Yes, but they are very fast compared to a 12+ hour spin-up. Personally, I think you're taking the wrong approach here in forcing load of a 50 GB structure. Just a suggestion, but we use HttpRuntime.Cache as part of a multi-tier caching strategy:
The point being, at load we don't require anything in memory - it is filled as it is needed, and from then on it is fast. We also use pub/sub (again courtesy of redis) to ensure cache invalidation is prompt. The net result: it is fast enough when cold, and very fast when warm.
Basically, I would look at anything that avoids needing the 50GB data before you can do anything.
If this data isn't really cache, but is your data, I would look at serialization on a proper object model. I would suggest protobuf-net (I'm biased as the author) as a strong candidate here - very fast and very small output.