I created test with JMeter to test performance of Ghost blogging platform. Ghost written in Node.js and was installed in cloud server with 1Gb RAM, 1 CPU.
Are you using cluster module to load-balance and Node 0.10.x?
If that's so, please update your node.js to 0.11.x.
Node 0.10.x was using balancing algorithm provided by an operating system. In 0.11.x the algorithm was changed, so it will be more evenly distributed from now on.