This a noob alike question, but here we go. I´ve read about Twitter Bootstrap (among other presentation frameworks), which gives the designer/programmer the tools to build easil
If you are Java-minded, you may like Tobacco, which I made just for that: http://tobacco.noroutine.me/.
Basically it's maven project template with latest js libs and latest Twitter Bootstrap.
There are some similar things around like this. One which is closest to your needs may be resthub especially their Backbone stack may be of interest.